200 Tablets Cetirizine Hydrochloride Zecet-10 OTC 10mg Box Antihistamine Anti-allergy

Cetirizine Hydrochloride is an allergy medication that you can buy over the counter (OTC) at a pharmacy. That is, you don’t need a prescription. Cetirizine comes in capsules and tablets. You typically take it just once per day, and it begins to work quickly. If you have year-round allergies or seasonal allergies like hay fever, your doctor may recommend cetirizine. Cetirizine may help relieve allergy symptoms.

When you come in contact with substances that you may be allergic to (allergens), your body produces a chemical called histamine. Histamine causes most of the symptoms related to allergic reactions.

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Cetirizine Hydrochloride is an allergy medication that you can buy over the counter (OTC) at a pharmacy. That is, you don’t need a prescription. Cetirizine comes in capsules and tablets. You typically take it just once per day, and it begins to work quickly. If you have year-round allergies or seasonal allergies like hay fever, your doctor may recommend cetirizine. Cetirizine may help relieve allergy symptoms.

When you come in contact with substances that you may be allergic to (allergens), your body produces a chemical called histamine. Histamine causes most of the symptoms related to allergic reactions.

Cetirizine is an antihistamine. It blocks the effects of histamine.

Cetirizine helps relieve mild to moderate allergy symptoms, such as:

  • sneezing
  • runny nose
  • itchy or watery eyes
  • itchy throat or nose

These reactions can happen after you touch or inhale allergens such as plant pollen, mold, or pet dander. Allergies usually affect your nose, sinuses, throat, and other areas of your upper respiratory system. Cetirizine also helps relieve hives. Hives are itchy, raised rashes on the skin. They often occur with food or medication allergies.

Interactions with cetirizine

Cetirizine does interact with other substances.

For example, avoid consuming alcoholic drinks while you take cetirizine. Doing so may be dangerous. Mixing cetirizine with alcohol can cause drowsiness or make you less alert.

If you take any type of tranquilizer, sedative, or sleep aid, make sure to mention this to your doctor before you use cetirizine.

Mixing cetirizine with drugs that depress your central nervous system can increase sleepiness. It can also further affect your mental and nervous system functions.

There is a possibility of a drug interaction between cetirizine and theophylline. Theophylline (Theo-24) is a drug that some people with asthma and other lung problems take.

In some instances when the two drugs were taken, it took longer for cetirizine to leave the body. However, the interaction may be dose-related. It has only been reported with daily theophylline doses of 400 mg or more.

PHARMACOLOGICAL ACTION:

Cetirizine is a metabolite of hydroxyzine, is an anti-allergic agent with a histamine H1 receptor antagonism devoid of any significant anticholinergic and anti serotonin effects as demonstrated in experimental and clinical pharmacology. At the present stage of research into the mode of action of cetirizine, the anti-allergic activity seems to be exerted mainly via its effects on the release of certain mediators, such as histamine, together with a selective action on the H1 receptors. ZECET reduces eosinophil recruitment induced by an antigen-antibody reaction.

PHARMACOKINETIC PROPERTIES:

Peak blood levels of 300 mg/ml. are reached within one hour after oral administration of cetirizine. Cetirizine does not undergo extensive first pass metabolism. The terminal half life is approximately 10 hours in adults, 6 hours in children aged 6 to 12 years and 5 hours in children aged 2 to 6 years. These data are consistent with the urinary excretion half-life of the drug. The cumulative urinary excretion represents about two-thirds of the dose given in both adults and children. The apparent plasma clearance in children is higher than that measured in adults. Plasma levels are linearly related to the dosage given. A high proportion of cetirizine is bound to human plasma proteins. In patients with impaired renal clearance (less than 40 ml/min) and hepatic insufficiency, an increase in half-life and decrease in total creatinine clearance occur.

INDICATIONS:

Allergic processes responding to a histamine H1 receptor antagonist. Respiratory: Allergic rhinitis, hay fever. Cutaneous: Allergic skin conditions associated with pruritis e.g. urticaria.

CONTRA-INDICATIONS:

History of hypersensitivity to any of the constituents of the formulations. Hypersensitivity to hydroxyzine. ZECET is contraindicated in lactating women since the active ingredient is excreted in breast milk. ZECET is contraindicated in pregnancy as the safety has not been established.

DOSAGE AND DIRECTIONS FOR USE:

Tablets:

Adults, or children 12 years of age or older: one 10 mg tablet daily. Children 6 to 12 years old: 10 mg (1 tablet) once daily or 5 mg (half a tablet) twice daily.

Oral solution:

Adults, or children 12 years of age ‘or older: 10 mg (10 ml) once daily. Children 6 to 12 years old: 10 mg (10 ml) daily, either as a single dose or as divided doses of 5 ml in the morning and 5 ml in the evening. Children 2 to 6 years old: 5 mg (5 ml) daily, either as a single dose or as divided doses of 2.5 ml in the morning and 2.5 ml in the evening. At present, there are no data to suggest that the dose needs to be reduced in elderly patients with normal renal function. In patients with renal insufficiency (creatinine clearance less than 40 ml/min), the dosage should be reduced to half the usual recommended dose. Half the recommended daily dose should be used in patients with moderate to severe hepatic impairment.

SIDE-EFFECTS AND SPECIAL PRECAUTIONS:

ZECET lacks significant sedative effects. Patients should, however, be warned that a small number of individuals may experience sedation. It is therefore advisable to determine the individual response before driving or performing complicated tasks. This. the effect may be compounded by the simultaneous intake of alcohol or other central nervous system depressants. There have been occasional reports of mild and transient subjective side- effects such as headache, dizziness, drowsiness, agitation, dry mouth, increased appetite, nervousness, fatigue, asthenia, malaise, nausea, and gastrointestinal discomfort. In some individuals, hypersensitivity reactions including skin reactions, urticaria, pruritus, and angioedema may develop. Interactions: To date, there are no known interactions with other drugs. Studies with diazepam, glipizide, pseudoephedrine, ketoconazole, azithromycin, erythromycin, and cimetidine have revealed no evidence of pharmacokinetic interactions. As with other antihistamines, it is advisable to avoid excessive alcohol consumption.

KNOWN SYMPTOMS OF OVERDOSAGE AND PARTICULARS OF ITS TREATMENT:

Drowsiness can be a symptom of overdosage. Overdosage in children may produce agitation, somnolence, pruritus, rash, urinary retention, fatigue, tremor, and tachycardia. In the case of massive overdosage, gastric lavage should be performed together with the usual supportive measures. To date there is no specific antidote. Cetirizine is not effectively removed by dialysis.

STORAGE INSTRUCTIONS:

Store in a cool, dark & dry place below 30°C. Keep tablets in a dry place.

EXP DATE: 04/2024

etirizine Hydrochloride 10mg 6 scaled

etirizine Hydrochloride 10mg 7 scaled

Brand

ZECET

Size

10mg

Contain

200 Tablets

Expiry

08/2024

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